Drug-resistant and immune-escape HBV mutants in HIV-infected hosts
نویسندگان
چکیده
منابع مشابه
Drug-resistant and immune-escape HBV mutants in HIV-infected hosts.
HIV-HBV-coinfected patients require optimal control of viral replication in order to prevent the development of severe comorbidities, such as liver cirrhosis and hepatocellular carcinoma. The genetic diversity of HBV is a poorly investigated factor of such viral replication in HIV-infected hosts. HBV genome diversity can be differentiated into two major aspects: genotypic and phenotypic. Genoty...
متن کاملDrug-resistant and immune-escape hepatitis B virus mutants in HIV-infected hosts
HIV-HBV infected patients require optimal control of viral replication in order to prevent severe comorbidities, such as liver cirrhosis and hepatocellular carcinoma. The genetic diversity of HBV is a poorly investigated factor of such viral replication in HIV-infected hosts. HBV genome diversity can be differentiated in two major aspects: genotypic and phenotypic. Genotypic diversity is more r...
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During infection with human immunodeficiency virus (HIV), immune pressure from cytotoxic T-lymphocytes (CTLs) selects for viral mutants that confer escape from CTL recognition. These escape variants can be transmitted between individuals where, depending upon their cost to viral fitness and the CTL responses made by the recipient, they may revert. The rates of within-host evolution and their co...
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Background and Aims: lamivudine is amongst the antiviral for drug chronic hepatitis B treatment. During therapy with lamivudine, variants may emerge with YMDD mutation in the reverse transcriptase (RT) region of polymerase gene. This mutation might have a role in drug resistant for HBV. Materials and Methods: HBV DNA extraction from serum sample of 88 patients, were subjected to nested PCR for ...
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We present computer simulations of the HIV infection based ona sophisticated cellular automata model of the immune response. The infection progresses following the well-known three-phase dynamics observed in patients, that is, acute, silent and acquired immunodeficiency.Antigenic shift and selection of escape viral mutants with low transcription rate explain the long term course of the asymptom...
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ژورنال
عنوان ژورنال: Antiviral Therap
سال: 2010
ISSN: 1359-6535
DOI: 10.3851/imp1495